Author: Lieven

Investigation of the biological indicator for vaccine efficacy against highly pathogenic avian influenza (HPAI) H5N1 virus challenge in mice and ferrets.
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Investigation of the biological indicator for vaccine efficacy against highly pathogenic avian influenza (HPAI) H5N1 virus challenge in mice and ferrets.

To analyze the organic indicator for vaccine efficacy in opposition to HPAI H5N1 virus problem of various clades, two inactivated whole-virus H5N1 vaccines containing the hemagglutinin (HA) and neuraminidase (NA) genes of both clade 2.2 A/EM/Korea/W149/06 (RgKoreaW149/06 x PR8) or clade 2.5 A/Ck/Korea/ES/03 (RgKoreaES223N/03XPR8) virus within the background of A/PR/8/34 (H1N1) had been generated by […]

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Prime-boost vaccination with a fowlpox vector and an inactivated avian influenza vaccine is highly immunogenic in Pekin ducks challenged with Asian H5N1 HPAI.
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Prime-boost vaccination with a fowlpox vector and an inactivated avian influenza vaccine is highly immunogenic in Pekin ducks challenged with Asian H5N1 HPAI.

The efficacy of various vaccination schedules was evaluated in 17-day-old Pekin geese utilizing an experimental inactivated entire virus vaccine based mostly on the H5N9 A/hen/Italy/22A/98 isolate (H5N9-It) and/or a fowlpox recombinant (vFP-H5) expressing an artificial HA gene from an Asian H5N1 isolate (A/hen/Indonesia/7/2003). Full safety towards scientific indicators and shedding was induced by the totally […]

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Tedizolid

Introduction: Tedizolid phosphate is an oxazolidinone approved for the treatment of acute bacterial infections of the skin and skin structure (ABSSSI) and active against methicillin-resistant Staphylococcus aureus. Objectives: The objective of this article was to review the evidence for the efficacy and safety of tedizolid phosphate for the treatment of ABSSSI. Review of evidence: Approval […]

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Istaroxime hydrochloride

General description: Product group: Chemicals Category: Other CAS No: 374559-48-5 Properties: Purity:> 98% Molecular Formula: C21H33ClN2O3 Molecular weight: 396.95 UNSPSC: 12352200 Scientific information: Istaroxime Hcl (PST-2744 Hcl) is a positive inotropic agent that mediates its action by inhibiting sodium / potassium adenosine triphosphatase (Na + / K + ATPase). IC50 value: 0.43 +/- 0.15 uM […]

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Brassinolide

Resume We conducted field and pot experiments to investigate the effects of brassinolide on 1-year-old Robinia pseudoacacia L. seedlings. In the field experiment, the roots of the seedlings were soaked in brassinolide solutions containing 0–0.4 mg / l of pure brassinolide before planting. Seedling survival and growth were determined 8 months later. The results showed […]

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Ruxolitinib (INCB018424)

Background Ruxolitinib dihydrochloride is a specific inhibitor of Janus-associated kinase (JAK1 and JAK2). Ruxolitinib is a small molecular with the formula C17H21N6O4P and a molecular weight of 404. Ruxolitinib phosphate is a cyclopentyl propionitrile derivative competitive with administered ATP and shows inhibitory activity on JAK1 and JAK2. Ruxolitinib inhibits phosphorylation of JAK1 / 2, STAT5, […]

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PCI-32765, BTK Inhibitor

Resume Small molecule drugs that target the B-cell antigen receptor (BCR) signalosome show clinical efficacy in the treatment of B-cell non-Hodgkin lymphoma. These agents, including Bruton’s tyrosine kinase (BTK) inhibitor PCI -32765, show an unexpected response in patients with chronic lymphocytic leukemia (CLL): a rapid and sustained reduction in lymphadenopathy accompanied by transient lymphocytosis, which […]

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A Systematic Evaluation of Measures Against Highly Pathogenic Avian Influenza (HPAI) in Indonesia.
Camel

A Systematic Evaluation of Measures Against Highly Pathogenic Avian Influenza (HPAI) in Indonesia.

Over the previous years, many alternative management measures have been applied to forestall HPAI an infection. The nationwide plan with quite a few measures result in issues when it comes to prioritization and funds allocation. Our research goals are to (i) set up a list of measures on HPAI management in Indonesia because the first […]

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